OptiWize Collagen +Plus Dogs and Cat Joints Health Supplement

Martí-Angulo, S., García-López, N., & Díaz-Ramos, A. (2014). Efficacy of an oral hyaluronate and collagen supplement as a preventive treatment of elbow dysplasia. Journal of Veterinary Science, 15(4), 569–574. https://doi.org/10.4142/jvs.2014.15.4.569

-This white paper outlines the importance of proactive joint care for dogs, focusing on the anatomy and function of joints, the role of cartilage and synovial fluid, and how degradation can lead to arthritis. It emphasizes early intervention and the use of joint supplements for dogs containing ingredients like glucosamine, chondroitin, and hyaluronic acid to help maintain mobility, reduce discomfort, and support long-term joint health in dogs of all ages.



Cline, J. (2024). Ultimate hip and joint management [White paper]. Hollywood Feed University. https://hfu.hollywoodfeed.com/wp-content/uploads/2024/03/hip_joint_whitepaper2.pdf

-This white paper discusses the importance of joint health in dogs, highlighting the anatomy of joints and cartilage, the role of synovial fluid, and the balance between synthesis and degradation of cartilage components. It emphasizes the significance of early joint care and maintenance to prevent conditions like osteoarthritis in dogs.

Martello, E., Bigliati, M., Adami, R., Biasibetti, E., Bisanzio, D., Meineri, G., & Bruni, N. (2022). Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial. PLOS ONE, 17(2), e0263971. https://doi.org/10.1371/journal.pone.026397

-This study evaluated the effects of a dietary supplement containing glucosamine, chondroitin sulfate, hyaluronic acid, collagen, and other ingredients on dogs with osteoarthritis. Over a 60-day period, the treatment group showed significant improvements in clinical signs and pain reduction compared to the placebo group, with no reported side effects.

Wenz, W., Hornung, C., Cramer, C., Schroeder, M., & Hoffmann, M. (2006). The effect of glucosamine sulfate on osteoarthritis in the cruciate-deficient canine model of osteoarthritis. Osteoarthritis and Cartilage, 14(5), 403–411. https://doi.org/10.1016/j.joca.2006.01.005

-This study investigated the effects of glucosamine sulfate on osteoarthritis progression in a canine model with induced anterior cruciate ligament deficiency. The findings indicated that glucosamine sulfate treatment significantly reduced cartilage degradation and improved joint function compared to the control group.

Serra Aguado, C. I., Ramos-Plá, J. J., Soler, C., Segarra, S., Moratalla, V., & Redondo, J. I. (2021). Effects of oral hyaluronic acid administration in dogs following tibial tuberosity advancement surgery for cranial cruciate ligament injury. Animals, 11(5), 1264. https://doi.org/10.3390/ani11051264

-This study evaluated the effects of oral hyaluronic acid (HA) administration on synovial fluid biomarkers in dogs undergoing tibial tuberosity advancement (TTA) surgery for cranial cruciate ligament (CCL) injury. The findings indicated that oral HA supplementation led to significant improvements in certain osteoarthritis biomarkers, suggesting its potential efficacy in managing stifle osteoarthritis post-surgery.