MSM (Methylsulfonylmethane) supplementation is an organic sulfur compound that is derived from the sulfur compound dimethyl sulfoxide (DMSO). MSM is primarily known for its potential benefits in promoting joint health, but has additional benefits like anti- aging. In this blog we will go more in depth in MSM and explore the science and benefits.

What Is MSM and Why Does It Matter?
Many people wonder: what is MSM? At its core, it is a naturally occurring sulfur compound found in plants, animals, and humans. Sulfur is an essential element for many biological processes, including the formation of proteins and connective tissue. Because of its role in these processes, MSM is often consumed as a methylsulfonylmethane supplement to support structural health and wellness.
When considering what MSM is good for, it is often linked to supporting joints, skin, and muscle recovery. While no supplement is a cure-all, MSM’s role as a sulfur donor makes it particularly interesting in nutrition science. The compound has been studied for its involvement in collagen production, antioxidant defense, and the regulation of inflammation-related pathways.
Scientific Facts:
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A double-blinded study conducted on humans demonstrated that oral supplementation of MSM led to a substantial reduction in pain associated with degenerative arthritis compared to the placebo group that did not receive MSM. This outcome was observed as early as week 4 of the study.
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MSM exhibits anti-inflammatory properties by reducing cytokine expression, as evidenced by in vitro studies and animal research. The decrease in cytokine expression indicates its potential as an effective anti-inflammatory agent.
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Research conducted on osteoarthritis patients revealed that MSM supplementation resulted in a significant decrease in cartilage surface degeneration. This finding highlights the potential of MSM in preserving cartilage health and mitigating the progression of osteoarthritis.
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MSM's antioxidant properties make it beneficial in combating oxidative stress. By acting as an antioxidant, MSM can neutralize free radicals present in the body. This ability to counteract free radicals helps protect cells and tissues from oxidative damage.
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A double blinded study was done to test MSM on the health and condition of skin for aging effects. There was a significant improvement in wrinkle count, skin firmness, tone and texture. It is believed it is because of MSM’s effect on gene regulation.
Methylsulfonylmethane Benefits:
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Reduction of Joint Pain: MSM supplementation has analgesic properties in relation to joint pain. It can help alleviate pain associated with conditions like osteoarthritis.
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Decreased Joint Inflammation: Inflammation plays a significant role in joint diseases, including arthritis. MSM exhibits anti-inflammatory properties and may help reduce joint inflammation. MSM supplementation could contribute to decreased joint swelling, tenderness, and stiffness.
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Improved Joint Mobility: Joint stiffness and reduced mobility are common symptoms of joint conditions. MSM supplementation has been associated with improved joint flexibility and increased range of motion. This can help individuals with joint issues to experience greater ease of movement and enhanced physical functioning.
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Preservation of Cartilage Integrity: Cartilage is the protective tissue that cushions the ends of bones in joints. In joint diseases such as osteoarthritis, cartilage degradation is a major concern. MSM has been suggested to support cartilage health by aiding in the synthesis of collagen and other connective tissue components. This may help preserve cartilage integrity and slow down its degeneration.
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Exercise Recovery: MSM can decrease soreness and inflammation after intense activity. As well as its ability to have antioxidant properties to prevent oxidative damage.
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Anti- aging: MSM can improve you the tone, texture and skin firmness as well as reducing lines and wrinkles.
Sources of MSM in Food
Some people prefer natural dietary intake, leading to the question of methylsulfonylmethane in food. MSM can be found in small amounts in fruits, vegetables, grains, and even milk. Foods such as broccoli, Brussels sprouts, garlic, and onions are known to contain sulfur compounds that may contribute to similar functions in the body.
However, the amount of MSM naturally present in food is often low. This is why many people explore methylsulfonylmethane supplement options, as they can deliver more concentrated and consistent levels of the compound. Supplements provide an opportunity for individuals to experiment with intake levels that may be higher than those possible through diet alone.
Uses of MSM beyond Joints
Although MSM is widely associated with joint support, there are broader methylsulfonylmethane uses that continue to attract interest. These include:
Skin Health: Some studies suggest MSM may contribute to improved skin elasticity and appearance, making it a focus in the beauty and wellness industry.
Muscle Support: Athletes often explore MSM as part of recovery routines after strenuous workouts.
Immune Function: Because of its antioxidant and sulfur-donating properties, MSM is sometimes examined for its role in supporting the body’s defense systems.
By looking at methylsulfonylmethane benefits beyond joint support, individuals can better understand how it might fit into a balanced health routine.
MSM for Hair and Beauty
Another area of growing popularity is MSM for hair. Sulfur plays a key role in keratin production, which is the main structural protein in hair. Some people explore methylsulfonylmethane for human wellness routines as a way to support hair growth and strength. While research is still developing, anecdotal reports and early studies suggest that MSM may influence hair density and overall appearance.
In addition, MSM’s antioxidant properties have been studied for their potential impact on skin, where improved tone and hydration have been observed in some trials. Combined, these properties make MSM a versatile compound for individuals interested in overall appearance and beauty.
Conclusion
MSM is more than just a joint-focused compound—it is a versatile organic sulfur supplement that may contribute to various aspects of health and wellness. Whether sourced from food or taken as a methylsulfonylmethane supplement, this compound continues to be researched for its role in skin, hair, and joint support.
By recognizing methylsulfonylmethane uses, and exploring sources like MSM in food, individuals can make informed choices about whether to include it in their routines. From MSM for hair to its potential in supporting connective tissue, the range of methylsulfonylmethane benefits continues to make it a popular topic in nutrition and wellness.
Reference data:
Ronald M. Lawrence, M.D., Ph.D. Assistant Clinical Professor U.C.L.A. School of Medicine Los Angeles, California
"METHYL-SULFONYL-METHANE (M.S.M.)
A DOUBLE BLIND STUDY OF ITS USE IN DEGENERATIVE ARTHRITIS"
Read full Article here
Michael Anthonavage, Natural Medicine Journal, November 4, 2015
"Effects of Oral Supplementation With Methylsulfonylmethane on Skin Health and Wrinkle Reduction"
Read full Article here
Matthew Butawan, Rodney L. Benjamin and Richard J. Bloomer
"Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement"