MSM (Methylsulfonylmethane) - Benefits and Scientific Facts

MSM (Methylsulfonylmethane) - Benefits and Scientific Facts

MSM (Methylsulfonylmethane) supplementation is an organic sulfur compound that is derived from the sulfur compound dimethyl sulfoxide (DMSO). MSM is primarily known for its potential benefits in promoting joint health, but has additional benefits like anti- aging. In this blog we will go more in depth in MSM and explore the science and benefits.


Methylsulfonylmethane Toxisicity Data

Scientific Facts:

  1. A double-blinded study conducted on humans demonstrated that oral supplementation of MSM led to a substantial reduction in pain associated with degenerative arthritis compared to the placebo group that did not receive MSM. This outcome was observed as early as week 4 of the study.

  2. MSM exhibits anti-inflammatory properties by reducing cytokine expression, as evidenced by in vitro studies and animal research. The decrease in cytokine expression indicates its potential as an effective anti-inflammatory agent.

  3. Research conducted on osteoarthritis patients revealed that MSM supplementation resulted in a significant decrease in cartilage surface degeneration. This finding highlights the potential of MSM in preserving cartilage health and mitigating the progression of osteoarthritis.

  4. MSM's antioxidant properties make it beneficial in combating oxidative stress. By acting as an antioxidant, MSM can neutralize free radicals present in the body. This ability to counteract free radicals helps protect cells and tissues from oxidative damage.

  5. A double blinded study was done to test MSM on the health and condition of skin for aging effects. There was a significant improvement in wrinkle count, skin firmness, tone and texture. It is believed it is because of MSM’s effect on gene regulation.


  1. Reduction of Joint Pain: MSM supplementation has analgesic properties in relation to joint pain. It can help alleviate pain associated with conditions like osteoarthritis.

  2. Decreased Joint Inflammation: Inflammation plays a significant role in joint diseases, including arthritis. MSM exhibits anti-inflammatory properties and may help reduce joint inflammation. MSM supplementation could contribute to decreased joint swelling, tenderness, and stiffness.

  3. Improved Joint Mobility: Joint stiffness and reduced mobility are common symptoms of joint conditions. MSM supplementation has been associated with improved joint flexibility and increased range of motion. This can help individuals with joint issues to experience greater ease of movement and enhanced physical functioning.

  4. Preservation of Cartilage Integrity: Cartilage is the protective tissue that cushions the ends of bones in joints. In joint diseases such as osteoarthritis, cartilage degradation is a major concern. MSM has been suggested to support cartilage health by aiding in the synthesis of collagen and other connective tissue components. This may help preserve cartilage integrity and slow down its degeneration.

  5. Exercise Recovery: MSM can decrease soreness and inflammation after intense activity. As well as its ability to have antioxidant properties to prevent oxidative damage.

  6. Anti- aging: MSM can improve you the tone, texture and skin firmness as well as reducing lines and wrinkles.

In conclusion, MSM supplementation offers numerous benefits for joint health, making it a valuable addition to your wellness routine. By incorporating MSM into your daily regimen, you can experience a positive impact on your overall well-being.

Reference data:

Ronald M. Lawrence, M.D., Ph.D. Assistant Clinical Professor U.C.L.A. School of Medicine Los Angeles, California
Read full Article here

Michael Anthonavage, Natural Medicine Journal, November 4, 2015
"Effects of Oral Supplementation With Methylsulfonylmethane on Skin Health and Wrinkle Reduction"
Read full Article here


Matthew Butawan, Rodney L. Benjamin and Richard J. Bloomer
"Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement"


Read all available scientific documentation

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